Current activities

• SmartAlgos IT-Consulting
• GeneTalk GmbH
  • Gestaltmatcher An image database and KI for finding rare genetic diseases using facial phenotypic descriptors.
  • FindMe2Care Patient database for rare genetic diseases.
  • GeneTalk Variant Analyser the internet platform for analyzing human sequence variants.
• BioPhysio medical wellness
• HTW Berlin

GitHub

• GeneTalkTK

Publications

• Google Scholar
• Research Gate

Doctoral thesis

• Models and Algorithms for Online Exploration and Search
  University of Bonn, 2005.

Proceedings, articles, reports

1. Hellen Lesmann, Tom Kamphans, Peter Krawitz, Tzung-Chien Hsieh et. al.
   GestaltMatcher Database - a FAIR database for medical imaging data of rare diseases
   Abstr. ACMG Ann. Clincal Genetics Meeting, 2023.

2. Tzung-Chien Hsieh, Luisa Averdunk, C. C. Mak, Tom Kamphans, Wolfgang Meiswinkel, Peter M. Krawitz
   GestaltMatcher research platform facilitates the novel gene-phenotype explora
   Proc. 32nd Annual Meeting of the German Society of Human Genetics, 2022, pp. 8.

3. Tzung-Chien Hsieh, Aviram Bar-Haim, Shahida Moosa, et al.
   GestaltMatcher facilitates rare disease matching using facial phenotype descriptors
   Nature Genetics, pp. 349-357, 2022.

4. Chengyao Peng, Simon Dieck, Alexander Schmid, Ashar Ahmad, Alexej Knaus, Maren Wenzel, Laura Mehnert, Birgit Zirn, Tobias Haack, Stephan Ossowski, Matias Wagner, Theresa Brunet, Nadja Ehmke, Magdalena Danyel, Stanislav Rosnev, Tom Kamphans, Guy Nadav, Nicole Fleischer, Holger Fröhlich, Peter Krawitz
   CADA: phenotype-driven gene prioritization based on a case-enriched knowledge graph
   NAR Genomics and Bioinformatics 3(3), 2021.

5. Hsieh, Tzung-Chien, Bar-Haim, Aviram, Moosa, Shahida, Ehmke, Nadja, Gripp, Karen W., Pantel, Jean Tori, Danyel, Magdalena, Mensah, Martin Atta, Horn, Denise, Fleischer, Nicole, Bonini, Guilherme, Schmid, Alexander, Knaus, Alexej, Sivalingam, Sugirthan, Kamphans, Tom, Ebstein, Frédéric, Krüger, Elke, Küry, Sébastien, Bézieau, Stéphane, Schmidt, Axel, Peters, Sophia, Engels, Hartmut, Mangold, Elisabeth, Kreiß, Martina, Cremer, Kirsten, Perne, Claudia, Betz, Regina C., Grundmann-Hauser, Kathrin, Haack, Tobias, Wagner, Matias, Brunet, Theresa, Bentzen, Heidi Beate, Spielmann, Malte, Schaaf, Christian, Mundlos, Stefan, Nöthen, Markus M., Krawitz, Peter
   GestaltMatcher: Overcoming the limits of rare disease matching using facial phenotypic descriptors
   medRxiv, 2021.

6. T. Hsieh, A. Bar-Haim, D. Dukic, T. J. Pantel, M. Mensah, Y. Gurovich, N. Fleischer, Y. Hanani, T. Kamphans, G. Nadav, P Krawitz
   GestaltMatcher: Identifying the second patient of its kind in the phenotype space
   Europ J Human Genetics 27, pp. 1159-1159, 2019.

7. Tzung-Chien Hsieh, Peter Krawitz, et al
   PEDIA: prioritization of exome data by image analysis
   Genetics in Medicine, pp. 2807-2814, 2019.

8. Jean T. Pantel, Max Zhao, Martin A. Mensah, Nurulhuda Hajjir, Tzung-Chien Hsieh And Yair Hanani, Nicole Fleischer, Tom Kamphans, Stefan Mundlos, Yaron Gurovich, Peter M. Krawitz
   Advances in computer-assisted syndrome recognition by the example of inborn errors of metabolism
   J Inherit Metab Dis, pp. 1-7, 2018.

9. Jean T. Pantel, Max Zhao, Martin A. Mensah, Nurulhuda Hajjir, Tzung-Chien Hsieh, Yair Hanani, Nicole Fleischer, Tom Kamphans, Stefan Mundlos, Yaron Gurovich, Peter M. Krawitz
   Advances in computer-assisted syndrome recognition by the example of inborn errors of metabolism
   Abstr. Europ. Human Genetics Conf., 2018, pp. P16.17A / A.

10. Tzung-Chien Hsieh, Nurulhuda Hajjir, Jean T. Pantel, Martin A. Mensah, Max Zhao, Jacob Hertzberg, Max Schubach, Sebastian Köhler, Yaron Gurovich, Nicole Fleischer, Hilda David-Eden, Yair Hanani, Tom Kamphans, Denise Horn, Stefan Mundlos, Peter M. Krawitz
    Exploring molecular interactions by clustering analysis of similarity scores from next-generation phenotyping approaches
    Abstr. Europ. Human Genetics Conf., 2018, pp. P16.40D.

11. Verena Heinrich, Tom Kamphans, Stefan Mundlos, Peter N. Robinson, Peter M. Krawitz
    A likelihood ratio-based method to predict exact pedigrees for complex families from next-generation sequencing data
    Bioinformatics 33(1), pp. 72-78, 2017.

12. Jean Tori Pantel, Max Zhao, Martin Atta Mensah, Nurulhuda Hajjir, Tzung-Chien Hsieh, Yair Hanani, Nicole Fleischer, Tom Kamphans, Stefan Mundlos, Yaron Gurovich, Peter M. Krawitz
    Advances in computer-assisted syndrome recognition and differentiation in a set of metabolic disorders
    bioRxiv Genetics, 2017.

13. Verena Heinrich, Tom Kamphans, Stefan Mundlos, Peter N. Robinson, Peter M. Krawitz
    Prediction of complex pedigree structures from NGS data
    27th Annual Meeting of the German Society of Human Genetics,
    Medizinische Genetik 28, 2016, pp. 120.

14. Verena Heinrich, Tom Kamphans, Peter N. Robinson, Peter M. Krawitz
    "A likelihood ratio based method to predict exact pedigrees for
    Abstracts European Human Genetics Conference,
    Europ. J. Human Genetics 24, E-Suppl. 1, 2016, pp. 352.

15. Zhu Na, Verena Heinrich, Thorsten Dickhaus, Jochen Hecht, Peter N. Robinson, Stefan Mundlos, Tom Kamphans, Peter M. Krawitz
    Strategies to improve the performance of rare variant association studies by optimizing the selection of controls
    Bioinformatics 31(22), pp. 3577-3583, 2015.

16. Zhu Na, Verena Heinrich, Thorsten Dickhaus, Jochen Hecht, Peter N. Robinson, Stefan Mundlos, Tom Kamphans, Peter M. Krawitz
    Strategies to improve the performance of rare variant rare disease association studies by optimizing the selection of controls
    26th Annual Meeting of the German Society of Human Genetics,
    Medizinische Genetik 27, 2015, pp. 97.

17. Peter M. Krawitz, Tom Kamphans
    How to find the second patient of its kind
    26th Annual Meeting of the German Society of Human Genetics,
    Medizinische Genetik 27, 2015, pp. 136.

18. Sándor P. Fekete, Tom Kamphans, Nils Schweer
    Online Square Packing with Gravity
    Algorithmica 68, pp. 1019-1044, 2014.

19. Verena Heinrich, Tom Kamphans, Jens Stange, Dmitri Parkhomchuk, Thorsten Dickhaus, Jochen Hecht, Stefan Mundlos, Peter N Robinson, Peter M Krawitz
    Estimating exome genotyping accuracy by comparing to data from large scale sequencing projects
    24th Annual Meeting of the German Society of Human Genetics,
    Medizinische Genetik 25, 2013, pp. 174.

20. Tom Kamphans, Peggy Sabri, Na Zhu, Verena Heinrich, Stefan Mundlos, Peter N. Robinson, Dmitri Parkhomchuk, Peter M. Krawitz
    Filtering for Compound Heterozygous Sequence Variants in Non-Consanguineous Pedigrees
    PLoS ONE 8(8), 2013.

21. Tom Kamphans, Peggy Sabri, Verena Heinrich, Peter N. Robinson, Peter M. Krawitz
    Filtering for compound heterozygous sequence variants in non-consanguineous pedigrees
    Poster Abstr. 63th Annu. Meeting Am. Society of Human Genetics , 2013, pp. 323.

22. Verena Heinrich, Tom Kamphans, Jens Stange, Dmitri Parkhomchuk, Thorsten Dickhaus, Jochen Hecht, Peter Nick Robinson, Peter M. Krawitz
    Estimating Exome Genotyping Accuracy by Comparing to Data from Large Scale Sequencing Projects
    Genome Medicine 2013 5:69, 2013.

23. Tom Kamphans, Peter Krawitz, Peggy Sabri, Alexej Knaus
    GeneTalk: a compound heterozygotes filter for exome data
    Abstracts European Human Genetics Conference,
    Europ. J. Human Genetics 21, Suppl. 2, 2013, pp. 369.

24. Verena Heinrich, Tom Kamphans, Jens Stange, Dmitri Parkhomchuk, Thorsten Dickhaus, Jochen Hecht, Stefan Mundlos, Peter N Robinson, Peter M Krawitz
    Estimating exome genotyping accuracy by comparing to data from large scale sequencing projects
    Abstracts European Human Genetics Conference,
    Europ. J. Human Genetics 21, Suppl. 2, 2013, pp. 375.

25. Josef Angermeier, Sándor P. Fekete, Tom Kamphans, Dirk Koch, Nils Schweer, Jürgen Teich, Christopher Tessars, Jan C. van der Veen
    Dynamic Defragmentation of Reconfigurable Devices
    ACM Transact. Reconfig. Techn. Syst. 5 (2), 2012.

26. Tom Kamphans, Peter M. Krawitz
    GeneTalk: An expert exchange platform for assessing rare sequence variants in personal genomes
    Bioinformatics 28 (19), pp. 2515-2516, 2012.

27. Tom Kamphans, Peter M. Krawitz
    GeneTalk: An expert exchange platform for assessing rare sequence variants in personal genomes
    Poster Abstr. 62th Annu. Meeting Am. Society of Human Genetics, 2012.

28. Tom Kamphans, Peter M. Krawitz
    GeneTalk: An expert exchange platform for assessing rare sequence variants in personal genomes
    Abstracts European Human Genetics Conference,
    Europ. J. Human Genetics 20, Suppl. 1, 2012, pp. 280.

29. Michael Stelzer, Jibin Sun, Tom Kamphans, Sándor P. Fekete, An-Ping Zeng
    An extended bioreaction database that significantly improves reconstruction and analysis of genome-scale metabolic networks
    Integrative Biology 3(11), pp. 1071-1086, 2011.

30. Tobias Baumgartner, Sándor P Fekete, Tom Kamphans, Alexander Kröller, Max Pagel, Matthias Gietzelt, Reinhold Haux
    Demo abstract: using a sensor network to enhance a standardized medical test
    Europ. Conf. Wireless Sensor Networks, 2011.

31. Sándor P. Fekete, Henning Hasemann, Tom Kamphans, Christiane Schmidt
    Geometric Motion Planning: Finding Intersections
    Abstracts 27th European Workshop Comput. Geom., 2011, pp. 189-192.

32. Henning Hasemann, Tom Kamphans, Alexander Kröller
    Searching for Radio Beacons with Mobile Agents that Perceive Discrete Signal Intensities
    Abstracts 27th European Workshop Comput. Geom., 2011, pp. 159-162.

33. Sándor P. Fekete, Tom Kamphans, Alexander Kröller, Joseph S.B. Mitchell, Christiane Schmidt
    Exploring and Triangulating a Region by a Swarm of Robots
    14th Internat. Workshop Approx. Algor. Combin. Optim. Prob.,
    Lecture Notes Comput. Sci. 6845, Springer, 2011, pp. 206-217.

34. Rolf Klein, Tom Kamphans
    Pledge's Algorithm: How to Escape from a Dark Maze
    In Algorithms Unplugged,
    edited by Berthold Vöcking, Helmut Alt, Martin Dietzfelbinger, Rüdiger Reischuk, Christian Scheideler, Heribert Vollmer, Dorothea Wagner, Springer, 2011, pp. 69-75.

35. Rudolf Fleischer, Tom Kamphans, Rolf Klein, Elmar Langetepe, Gerhard Trippen
    The Tourist in the Shopping Arcade
    J. Universal Comput. Sci. 16(5), pp. 676-685, 2010.

36. Tobias Baumgartner, Sándor P. Fekete, Tom Kamphans, Alexander Kröller, Max Pagel
    Hallway Monitoring: Distributed Data Processing with Wireless Sensor Network
    Proc. 4th Workshop on Real-World Wireless Sensor Networks,
    Lecture Notes Comput. Sci. 6511, 2010, pp. 94-105.

37. Tom Kamphans, Elmar Langetepe
    Leaving an unknown maze using an error-prone compass
    Internat. J. Comput. Geom. Appl. 20, pp. 307-325, 2010.

38. Josef Angermeier, Sándor P. Fekete, Tom Kamphans, Nils Schweer, Jürgen Teich
    Virtual Area Management: Multitasking on Dynamically Partially Reconfigurable Devices
    Proc. 17th Reconf. Architect. Workshop, 2010.

39. Sándor P. Fekete, Tom Kamphans, Alexander Kröller, Christiane Schmidt
    Robot Swarms for Exploration and Triangulation of Unknown Environments
    Abstracts 26th European Workshop Comput. Geom., 2010, pp. 153-156.

40. Tom Kamphans, Elmar Langetepe
    Inspecting a set of strips optimally
    Proc. 20th Algorithms and Data Structure Symposium (WADS),
    Lecture Notes Comput. Sci. 5664, Springer, 2009, pp. 423-434.

41. Tom Kamphans, Elmar Langetepe
    Inspecting a set of strips optimally
    Abstracts 25th European Workshop Comput. Geom., 2009, pp. 163-166.

42. Michael A. Bender, Sándor P. Fekete, Tom Kamphans, Nils Schweer
    Maintaining Arrays of Contiguous Objects
    Proc. 17th Internat. Sympos. Fund. Comput. Theory,
    Lecture Notes Comput. Sci. 5699, 2009, pp. 14-25.

43. Sándor P. Fekete, Tom Kamphans, Nils Schweer
    Online Square Packing
    Proc. 20th Algorithms and Data Structure Symposium (WADS),
    Lecture Notes Comput. Sci. 5664, Springer, 2009, pp. 302-314.

44. Sándor P. Fekete, Tom Kamphans, Nils Schweer
    Online Square Packing
    Abstracts 25th European Workshop Comput. Geom., 2009, pp. 269-272.

45. Ali Ahmadinia, Josef Angermeier, Sándor P. Fekete, Diana Göhringer, Tom Kamphans, Dirk Koch, Mateusz Majer, Nils Schweer, Jürgen Teich, Christopher Tessars, Jan C. van der Veen
    ReCoNodes - Optimization Methods for Module Scheduling and Placement on Reconfigurable Hardware Devices
    In Dynamically Reconfigurable Systems: Architectures, Design Methods and Applications,
    edited by Marco Platzner, Jürgen Teich, Norbert Wehn, Springer, 2009, pp. 199-221.

46. Rudolf Fleischer, Tom Kamphans, Rolf Klein, Elmar Langetepe, Gerhard Trippen
    Competitive online approximation of the optimal search ratio
    Siam J. Comput., pp. 881-898, 2008.

47. Daniel Herrmann, Tom Kamphans, Elmar Langetepe
    Exploring Simple Triangular and Hexagonal Grid Polygons Online
    Abstracts 24th European Workshop Comput. Geom., 2008, pp. 177-180.

48. Rolf Klein, Tom Kamphans
    Der Pledge-Algorithmus: Wie man im Dunkeln aus einem Labyrinth entkommt
    In Taschenbuch der Algorithmen,
    edited by Berthold Vöcking, Helmut Alt, Martin Dietzfelbinger, Rüdiger Reischuk, Christian Scheideler, Heribert Vollmer, Dorothea Wagner, eXamen.press , Springer, 2008, pp. 75-81.

49. Tom Kamphans, Elmar Langetepe
    Leaving an unknown maze using an error-prone compass
    Accepted for Internat. J. Comput. Geom. Appl., 2008.

50. Josef Angermeier, Sándor P. Fekete, Tom Kamphans, Dirk Koch, Nils Schweer, Jürgen Teich, Christopher Tessars, Jan C. van der Veen
    No-Break Dynamic Defragmentation of Reconfigurable Devices
    Proc. Internat. Conf. Field Program. Logic Appl., 2008, pp. 113-118.

51. Daniel Herrmann, Tom Kamphans, Elmar Langetepe
    Exploring Simple Triangular and Hexagonal Grid Polygons Online
    Technical Report 007, Department of Computer Science I, University of Bonn, 2007.

52. Bernd Brüggemann, Tom Kamphans, Elmar Langetepe
    Escaping from a Labyrinth with One-way Roads for Limited Robots
    Abstracts 3rd European Conf. Mobile Robots, 2007.

53. Bernd Brüggemann, Tom Kamphans, Elmar Langetepe
    Leaving an Unknown Maze with One-Way Roads
    Abstracts 23rd European Workshop Comput. Geom., 2007, pp. 90-93.

54. Bernd Brüggemann, Tom Kamphans, Elmar Langetepe
    Leaving an Unknown Maze with One-Way Roads
    Abstracts 12th European Conf. Operational Research, 2007, pp. 140.

55. Andrea Eubeler, Rudolf Fleischer, Tom Kamphans, Rolf Klein, Elmar Langetepe, Gerhard Trippen
    Searching for rays and lower bound constructions
    Abstracts 12th European Conf. Operational Research, 2007, pp. 65.

56. Andrea Eubeler, Rudolf Fleischer, Tom Kamphans, Rolf Klein, Elmar Langetepe, Gerhard Trippen
    Competitive Online Searching for a Ray in the Plane
    Robot Navigation,
    Dagstuhl Seminar Proceedings , Internationales Begegnungs- und Forschungszentrum für Informatik (IBFI), Schloss Dagstuhl, Germany, 2006.

57. Birgit Engels, Tom Kamphans
    Randolph's Robot Game is NP-hard!
    Electronic Notes in Discrete Mathematics 25, pp. 49-53, 2006.

58. Birgit Engels, Tom Kamphans
    On the Complexity of Randolph's Robot Game
    Technical Report 005, Department of Computer Science I, University of Bonn, 2005.

59. Tom Kamphans, Elmar Langetepe
    Optimal competitive online ray search with an error-prone robot
    Technical Report 003, Department of Computer Science I, University of Bonn, 2005.

60. Christian Icking, Tom Kamphans, Rolf Klein, Elmar Langetepe
    Exploring grid polygons online
    Technical Report 001, Department of Computer Science I, University of Bonn, 2005.

61. Andrea Eubeler, Rudolf Fleischer, Tom Kamphans, Rolf Klein, Elmar Langetepe, Gerhard Trippen
    Competitive Online Searching for a Ray in the Plane
    Abstracts 21st European Workshop Comput. Geom., 2005, pp. 107-110.

62. Christian Icking, Tom Kamphans, Rolf Klein, Elmar Langetepe
    Exploring simple grid polygons
    11th Internat. Comput. Combin. Conf.,
    Lecture Notes Comput. Sci. 3595, Springer, 2005, pp. 524-533.

63. Tom Kamphans, Elmar Langetepe
    Optimal competitive online ray search with an error-prone robot
    Proc. 4th Internat. Workshop Efficient Experim. Algorithms,
    Lecture Notes Comput. Sci. 3503, Springer, 2005, pp. 593-596.

64. Tom Kamphans, Elmar Langetepe
    On optimizing multi-sequence functionals for competitive analysis
    Abstracts 21st European Workshop Comput. Geom., 2005, pp. 111-114.

65. Rudolf Fleischer, Tom Kamphans, Rolf Klein, Elmar Langetepe, Gerhard Trippen
    Competitive online approximation of the optimal search ratio
    Proc. 12th Annu. European Sympos. Algorithms,
    Lecture Notes Comput. Sci. 3221, Springer-Verlag, 2004, pp. 335-346.

66. Rudolf Fleischer, Tom Kamphans, Rolf Klein, Elmar Langetepe, Gerhard Trippen
    Competitive search ratio of graphs and polygons
    Abstracts 20th European Workshop Comput. Geom.,
    Universidad de Sevilla, 2004, pp. 127-130.

67. Tom Kamphans, Elmar Langetepe
    Finding a door along a wall with an error afflicted robot
    Abstracts 20th European Workshop Comput. Geom.,
    Universidad de Sevilla, 2004, pp. 143-146.

68. Tom Kamphans, Elmar Langetepe
    The Pledge Algorithm Reconsidered under Errors in Sensors and Motion
    Proc. of the 1th Workshop on Approximation and Online Algorithms,
    Lecture Notes Comput. Sci. 2909, Springer, 2003, pp. 165-178.

69. Christian Icking, Thomas Kamphans, Rolf Klein, Elmar Langetepe
    On the competitive complexity of navigation tasks
    Sensor Based Intelligent Robots,
    Lecture Notes Comput. Sci. 2238, Springer, Berlin, 2002, pp. 245-258.

70. Tom Kamphans, Elmar Langetepe
    Online Bewegungsplanung für Roboter
    Vorlesungsskript, Universität Bonn, Institut für Informatik, 2002.

71. Tom Kamphans, Rolf Klein
    Bewegungsplanung für Roboter
    Vorlesungsskript, Universität Bonn, Institut für Informatik, 2001.

72. Christian Icking, Thomas Kamphans, Rolf Klein, Elmar Langetepe
    Exploring an Unknown Cellular Environment
    Abstracts 16th European Workshop Comput. Geom.,
    Ben-Gurion University of the Negev, 2000, pp. 140-143.

Software

• Tom Kamphans, Michael Stelzer
  SPUL: Shortest Path with Unique Labels
  C++ program, 2008.

• Ulrich Handel, Tom Kamphans, Elmar Langetepe, Wolfgang Meiswinkel
  PolyRobot - an environment for simulating strategies for robot navigation in polygonal scenes
  Java Applet, 2002.

• Ulrich Handel, Christian Icking, Tom Kamphans, Elmar Langetepe, Wolfgang Meiswinkel
  GridRobot - an environment for simulating exploration strategies in unknown cellular areas
  Java Applet, 2000.

• Geometry-Lab

Photographs

• Roomba-Art

Some of my talks

• Robot Swarms for Exploration and Triangulation of Unknown Environments, FRONTS 2nd Year General Assembly Meeting, Feb. 01, 2010, Barcelona, Spain: Animated slides (Apple Keynote file), Printable slides (PDF)
• Project ReCoNodes, Project Summary, Sept. 25, 2009, Karlsruhe, Germany: Animated slides (Apple Keynote file), Printable slides (PDF)
• Maintaining Arrays of Contiguous Objects, FCT 2009, Wrocƚaw, Poland
• Exploring Simple Triangular and Hexagonal Grid Polygons Online, EuroCG 2008, Nancy, France (Animated slides, Printable slides with notes)
• Leaving an Unknown Maze with One-Way Roads, EURO 2007, Prag
• PhD Talk 04.04.2006 (Animated slides, Printable slides with notes)
• Exploring Simple Grid Polygons, Cocoon 2005, Kunming, China (Animated slides, Printable slides with notes)
• Exploring Simple Grid Polygons, Bonn, July 2005
• Optimal Competitive Online Ray Search with an Error-Prone Robot, WEA '05, Santorini, Greece
• The Pledge Algorithm Reconsidered under Errors in Sensors and Motion, WAOA 2003, Budapest

Master thesis

• Torsten Emmerich, Tom Kamphans
  Hardwareunterstützung octreebasierter 3D-Graphik
  Universität Dortmund, 1997.

Former Affiliations

04/2011 - 09/2011 HTW Berlin, Fachbereich I
11/2007 - 01/2011 Braunschweig University, Algorithms Group
08/2000 - 10/2007 University of Bonn, Institute of Computer Science I
11/1998 - 07/2000 University of Hagen, Praktische Informatik VI